Generation of cellulose from Saccharum officinarum pseudostem bagasse and its application as solubility enhancer in albendazole solid formulation

Formulations of poorly aqueous soluble drugs in different polymers based on solid dispersion method have been used to improve its solubility and drug bioavailability. The aim this study was formulate albendazole utilising cellulose obtained from saccharum officinarum pseudostem bagasse characterised. Herein, a 32 factorial design factor out 9 combinations the generated (GC) lactose. In each case, combination blended with albendazole, processed using solvent-evaporation technique adjuvant into form (SD). SD granulated starch lubricated magnesium stearate. Thermal analysis differential scanning calorimetry (DSC) Fourier transmission infrared spectrophotometer (FT-IR) were carried cellulose, granules. micromeritic properties granules, entrapment efficacy dispersion-number constitution granules determined. DSC result showed amorphous GC FT-IR no compatibility or interaction problem functional peaks observed. exhibited micromeritics (p > 0.05); rate consolidation < 0.43 Carr’s indices 23.53, 93 % 4.33. dissolution rates after 10 60 mins 94.11 68.52 respectively. These peaked lactose at 20 each. Albendazole formulation sugarcane promised alternative for improved possible bioavailability enhancement.